Buy Pyrazolam Powder

Buy Pyrazolam Powder Online

Buy Pyrazolam Powder

Intro: Pyrazolam Powder

Pyrazolam is a synthetic compound belonging to the triazolobenzodiazepine (TBZD) class—a subclass of benzodiazepines known for their potent sedative and anxiolytic effects. Its chemical formula is C₁₆H₁₂BrN₅, and it typically appears as a white crystalline powder. Pyrazolam acts as a positive allosteric modulator of the GABA-A receptor, enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) in the central nervous system. This results in anxiolytic, hypnotic, and muscle relaxant properties.

Unlike many benzodiazepines, Pyrazolam is notable for its lack of active metabolites and relatively long elimination half-life of approximately 17 hours, making it detectable in serum for over 50 hours and in urine for up to six days.

Origin and Historical Development

Pyrazolam was first synthesized in the 1970s by Leo Sternbach and his team at Hoffmann-La Roche, the same chemists responsible for many early benzodiazepines. Despite its promising pharmacological profile, Pyrazolam was never marketed as a prescription drug.

It re-emerged in 2012 as a designer benzodiazepine, sold online as a “research chemical” and marketed as a legal alternative to regulated benzodiazepines. Unlike phenazepam or etizolam, which were approved in some countries, Pyrazolam was never commercially produced for medical use, making it one of the first benzodiazepines to appear solely in the “gray market”2.

Research Applications

Pyrazolam Powder is used in various scientific domains, particularly in neuropharmacology, forensic toxicology, and analytical chemistry:

1. Receptor Binding Studies

• Pyrazolam is used to study GABA-A receptor modulation, helping researchers understand how triazolobenzodiazepines influence inhibitory neurotransmission.
• It has high affinity for the α2 and α3 subunits, which are associated with anxiolytic effects.

2. Behavioral Pharmacology

• Animal models have shown that Pyrazolam produces anxiolytic effects without significant sedation, making it useful for studying dose-response relationships and receptor selectivity.

3. Toxicology and Metabolism

• Pyrazolam is excreted unchanged in urine, which simplifies detection in forensic settings.
• It is used to develop LC-MS/MS and GC-MS methods for identifying designer benzodiazepines in biological samples.

4. Reference Material Development

• Pyrazolam is included in certified reference standards for forensic labs and clinical toxicology, aiding in the validation of drug screening protocols.

Storage and Handling Guidelines

Proper storage of Pyrazolam Powder is essential to maintain its chemical integrity and ensure safety:

Storage Conditions:

• Temperature: Store at –20°C for long-term preservation.
• Containers: Use airtight, light-resistant containers, such as amber glass vials.
• Humidity: Keep in a dry environment with desiccants to prevent degradation.
• Labeling: Clearly mark containers with chemical name, hazard warnings, and expiration date.

Handling Precautions:

• Use personal protective equipment (PPE) including gloves, goggles, and lab coats.
• Handle in a fume hood or well-ventilated area.
• Avoid inhalation, ingestion, or skin contact.
• Dispose of waste according to hazardous chemical protocols.

According to its safe data sheetPyrazolam should be handled with care due to its potential for respiratory and neurological effects.

Legal and Regulatory Compliance

Pyrazolam’s legal status varies across jurisdictions due to its classification as a novel psychoactive substance (NPS):

🇺🇸 United States

• Not scheduled federally, but some states (e.g., Alabama) have classified it as a Schedule I substance.
• May be prosecuted under the Federal Analogue Act if intended for human consumption.
• Research use requires DEA registration and compliance with analytical standards.

🇨🇦 Canada

• Not explicitly listed under the Controlled Drugs and Substances Act, but may be treated as a Schedule IV analog.
• Importation and research use require Health Canada authorization.

🇦🇺 Australia

• Classified as a Schedule 4 (Prescription Only Medicine) under the Poisons Standard, though not approved for medical use.
• Only permitted for scientific research with approval from the Office of Drug Control.

🇪🇺 European Union

• Controlled in several member states:
  • Germany: Regulated under NpSG (New Psychoactive Substances Act) for industrial and scientific use only.
  • UK: Classified as a Class C drug under the Misuse of Drugs Act 1971 since May 2017.
  • Sweden: Listed as a hazardous substance since 2016.
• Monitored by the EMCDDA and Europol as part of the NPS early warning system.

🌏 Asia

• China: Increasingly regulated under synthetic drug control measures.
• Japan: Controlled under the Pharmaceutical Affairs Law and Narcotics Control Act.
• India: May fall under the NDPS Act if classified as a psychoactive analog.

In all regions, Pyrazolam is considered a high-risk compound, and its handling requires licensing, secure storage, and ethical oversight. EG-018 for sale

Final Thoughts

Pyrazolam Powder is a pharmacologically intriguing compound that exemplifies the complexities of designer benzodiazepines. Originally developed in pharmaceutical research, it re-emerged as a research chemical and recreational substance, prompting global regulatory scrutiny.

For researchers, Pyrazolam offers insights into GABAergic modulation, benzodiazepine pharmacology, and forensic toxicology. But its abuse potential, legal ambiguity, and safety risks demand rigorous control and responsible stewardship.