Buy Dimethocaine Powder Online: The Perfect Research Chemical

Buy Dimethocaine Powder Online: The Perfect Research Chemical

Dimethocaine Powder?

Dimethocaine, also known as Larocaine or DMC, is a synthetic compound classified as a local anesthetic and stimulant. Structurally, it is an ester of 4-aminobenzoic acid, similar to procaine, but with stimulant properties that resemble cocaine. Its chemical formula is C₁₆H₂₆N₂O₂, and it typically appears as a white to slightly yellow crystalline powder.

Dimethocaine acts as a dopamine reuptake inhibitor, meaning it blocks the reabsorption of dopamine in the brain, leading to elevated mood, increased alertness, and euphoria. While it is less potent than cocaine, it has been used as a legal alternative in some regions and is often categorized as a synthetic cocaine derivative. Buy Dimethocaine Powder

Origin and Historical Development

Dimethocaine was first synthesized in the 1930s by Hoffmann-La Roche, a Swiss pharmaceutical company, as a local anesthetic for use in dentistry, ophthalmology, and minor surgical procedures. It was marketed under the name Larocaine and gained popularity in the United States during the 1930s and 1940s.

However, due to its psychoactive effects and potential for abuse, it was gradually phased out in favor of safer alternatives like lidocaine and procaine. In the early 2000s, Dimethocaine re-emerged in the research chemical market, especially in Europe, where it was sold as a legal high and a cocaine substitute.

Research Applications

Dimethocaine is primarily used in pharmacological, toxicological, and neurochemical research:

1. Dopamine Transporter Studies

• Dimethocaine is used to study dopaminergic pathways and reward mechanisms in the brain.
• It has an IC₅₀ of 1.2 µM for dopamine reuptake inhibition, comparable to cocaine (0.7 µM).

2. Behavioral Pharmacology

• Animal models (rats and rhesus monkeys) are used to assess its substitution potential, locomotor stimulation, and addiction liability.

3. Local Anesthetic Research

• Its anesthetic properties are studied in comparison to other esters like procaine, focusing on nerve conduction blockade and sodium channel inhibition.

4. Analytical Chemistry

• Dimethocaine serves as a reference standard in forensic toxicology, particularly in LC-MS/MS and GC-MS methods for detecting synthetic stimulants.

Storage and Handling Guidelines

Dimethocaine is chemically stable but requires proper storage to maintain its purity and potency:

Storage Conditions:

• Temperature: Store at –20°C for long-term stability.
• Containers: Use airtight, light-resistant containers, preferably amber glass.
• Humidity: Keep in a dry environment with desiccants to prevent degradation.
• Labeling: Clearly mark with chemical name, hazard warnings, and expiration date.

Handling Precautions:

• Use PPE including gloves, goggles, and lab coats.
• Handle in a fume hood or well-ventilated area.
• Avoid inhalation, ingestion, or skin contact.
• Dispose of waste according to hazardous chemical protocols.

Dimethocaine carries hazard statements such as:

• H302: Harmful if swallowed
• H315: Causes skin irritation
• H319: Causes serious eye irritation
• H332: Harmful if inhaled

Legal and Regulatory Compliance

Dimethocaine’s legal status varies widely across jurisdictions due to its stimulant properties and potential for misuse.

🇺🇸 United States

• Not scheduled federally, but may be considered an analog of cocaine under the Federal Analogue Act.
• The DEA monitors its distribution, and possession for human consumption may be prosecuted.

🇨🇦 Canada

• Not explicitly listed under the Controlled Drugs and Substances Act, but may be treated as a Schedule I analog.
• Importation and research use require Health Canada authorization.

🇦🇺 Australia

• Dimethocaine is considered a Schedule 9 (Prohibited Substance) under the Poisons Standard.
• Only permitted for scientific research with approval from the Office of Drug Control.

🇪🇺 European Union

• Listed by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) as a synthetic cocaine derivative.
• Controlled in several member states:
  • Sweden: Classified as a harmful substance since 2019.
  • Germany and UK: Subject to national psychoactive substance laws.

Asia

• China: Increasingly regulated under synthetic drug control measures.
• Japan: Controlled under the Pharmaceutical Affairs Law and Narcotics Control Act.
• India: May fall under the NDPS Act if classified as a stimulant analog.

In all regions, Dimethocaine is considered a high-risk compound, and its handling requires licensing, secure storage, and ethical oversight.

Final Thoughts

Dimethocaine Powder is a compound with a fascinating dual identity: originally developed as a local anesthetic, it later gained notoriety as a legal stimulant and cocaine substitute. Its re-emergence in the research chemical market has prompted renewed interest in its pharmacological effects, abuse potential, and regulatory status.

For researchers, Dimethocaine offers valuable insights into dopamine reuptake inhibition, anesthetic pharmacology, and forensic detection. But its psychoactive properties, legal ambiguity, and safety concerns demand careful handling and responsible use.