Buy 5F ADB
5F ADB
5F-ADB, also known as 5F-MDMB-PINACA, is a highly potent synthetic cannabinoid that belongs to the indazole-3-carboxamide family. It was first identified in 2014 and quickly gained notoriety due to its extreme potency and association with numerous adverse health effects and fatalities. Buy 5F ADB.
Chemical Profile
- Full Name: Methyl (S)-2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate
- Formula: C₂₀H₂₈FN₃O₃
- Molar Mass: 377.46 g/mol
- Structure: Indazole-based compound with a fluorinated pentyl chain
Usage and Abuse
- Found in synthetic cannabis products (e.g., “Spice”, “K2”)
- Often sprayed onto plant material and sold as herbal incense
- Associated with numerous fatalities, especially in Japan and Europe between 2014–2017
Research Use Only
- No approved medical or commercial uses
- Available only as a reference standard for forensic and toxicological research
Neurological Impact of 5F-ADB
1. Dopaminergic Activation
- 5F-ADB significantly increases the firing rate of midbrain dopaminergic neurons, which are involved in reward, motivation, and addiction.
- This hyperactivation is mediated through CB1 receptors, the same receptors targeted by THC, but 5F-ADB acts as a full agonist, making its effects much stronger.
- When CB1 receptors are blocked (e.g., with antagonist AM251), 5F-ADB fails to activate these neurons, confirming its CB1-dependent mechanism.
2. Serotonergic System
- Unlike its strong effect on dopamine, 5F-ADB does not activate serotonergic neurons, which are involved in mood regulation, sleep, and cognition.
- This selective activation may explain why users report intense euphoria and psychosis but not typical hallucinogenic effects associated with serotonin-based drugs.
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5F-ADB?
5F-ADB, also known as 5F-MDMB-PINACA, is a potent synthetic cannabinoid belonging to the indazole-3-carboxamide family. It was developed to mimic the effects of Δ9-THC, the psychoactive compound in cannabis, but with significantly higher potency. It acts as a full agonist at the CB₁ receptor, making it one of the most powerful compounds in its class.
Originally marketed as a “legal high,” 5F-ADB has since become a focal point in forensic toxicology and pharmacological research due to its toxicity, abuse potential, and association with fatalities.
Chemical Composition and Classification
- IUPAC Name: Methyl (S)-2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate
- Molecular Formula: C₂₀H₂₈FN₃O₃
- Molar Mass: 377.46 g/mol
- Structure: Features an indazole core with a fluorinated pentyl chain and a dimethylbutanoate moiety
Classification:
- Synthetic Cannabinoid Receptor Agonist (SCRA)
- Designer Drug
- Schedule I Controlled Substance (in many jurisdictions)
Its extreme potency and full agonist activity at CB₁ receptors distinguish it from natural cannabinoids, which are typically partial agonists.
Development
5F-ADB was first identified in Japan in late 2014, following a series of unexplained deaths linked to herbal smoking mixtures. It quickly spread across global markets due to its legal ambiguity and high psychoactive effects.
Unlike pharmaceutical cannabinoids, 5F-ADB was not developed for therapeutic use. Instead, it emerged from clandestine laboratories, primarily in China and Eastern Europe, where chemists modified known cannabinoid structures to evade drug laws.
By 2018, 5F-ADB had become the most frequently seized synthetic cannabinoid in the United States, according to DEA reports.
Research Applications
Despite its risks, 5F-ADB has value in controlled scientific settings:
1. Receptor Pharmacology
- Used to study CB₁ and CB₂ receptor binding and signal transduction.
- Helps differentiate partial vs. full agonist effects in cannabinoid research.
2. Toxicology
- Investigated for its acute toxicity, including effects on the central nervous system, cardiovascular system, and respiratory function.
- Linked to psychomotor agitation, acute psychosis, and fatal overdoses.
3. Forensic Science
- Serves as a reference standard in LC-MS/MS and GC-MS protocols.
- Used to validate drug screening methods and postmortem toxicology.
4. Metabolic Studies
- Researchers have mapped its ester hydrolysis and oxidative defluorination pathways.
- Metabolites are used to develop urine and blood assays for detection.
Storage and Handling
Due to its instability and toxicity, 5F-ADB must be stored under strict conditions:
Storage Guidelines:
- Temperature: –20°C for long-term preservation
- Container: Amber glass vials with airtight seals
- Humidity: Store in a desiccated environment
- Labeling: Include hazard symbols, chemical name, and expiration date
Handling Precautions:
- Use PPE: gloves, goggles, lab coat
- Work in a fume hood
- Avoid skin contact and inhalation
- Dispose of waste via hazardous chemical protocols
Legal Compliance by Region
🇺🇸 United States
- Classified as a Schedule I substance under the Controlled Substances Act
- No accepted medical use; high potential for abuse
- Research requires DEA registration and strict documentation
🇨🇦 Canada
- Listed under Schedule II of the Controlled Drugs and Substances Act
- Importation and possession for research require Health Canada approval
- Included in forensic drug panels
🇦🇺 Australia
- Categorized as a Schedule 9 Prohibited Substance under the Poisons Standard
- Only permitted for scientific research with authorization from the Office of Drug Control
🇪🇺 Europe
- Controlled across multiple jurisdictions:
- Germany: Regulated under NpSG (New Psychoactive Substances Act)
- UK: Banned under the Psychoactive Substances Act 2016
- France and Sweden: Listed as narcotic substances
- Monitored by EMCDDA due to its role in over 25 confirmed deaths between 2015–2017
🌏 Asia
- Japan: Banned since December 2014 following multiple fatalities
- China: Included in synthetic drug control lists
- India: Increasingly regulated under the NDPS Act, though not always explicitly listed
- South Korea: Controlled under the Narcotics Control Act
Public Health and Safety Concerns
5F-ADB is considered one of the most toxic synthetic cannabinoids ever identified. Its low effective dose, high receptor affinity, and unpredictable effects have led to numerous cases of hospitalization, impaired driving, and death.
Authorities across the globe have issued warnings and implemented early warning systems to track its spread. In some cases, 5F-ADB has even been found adulterating CBD products, raising concerns about consumer safety.
Conclusion
5F-ADB exemplifies the challenges posed by synthetic cannabinoids in both scientific research and public health policy. While its pharmacological potency makes it a valuable tool in receptor studies, its toxicity, abuse potential, and legal complexity demand rigorous oversight.
Researchers working with 5F-ADB must adhere to strict safety protocols, ethical standards, and regional regulations to ensure responsible use. As synthetic cannabinoids continue to evolve, compounds like 5F-ADB serve as cautionary benchmarks in the intersection of chemistry, law, and health.
