Buy 1 4-Butanediol

Buy 1 4 Butanediol (BDO) for Research and Forensic Applications

Introduction

1,4-Butanediol

1,4-Butanediol (BDO) is a colorless, viscous liquid organic compound with the molecular formula C₄H₁₀O₂. It belongs to the family of diols, which are compounds containing two hydroxyl (-OH) groups. BDO is miscible in water and many organic solvents, making it a versatile chemical in both industrial and research settings.

Its structure—HO–CH₂–CH₂–CH₂–CH₂–OH—gives it unique reactivity, allowing it to serve as a precursor to various polymers and solvents. It is hygroscopic, meaning it readily absorbs moisture from the air, and has a boiling point of approximately 235°C and a melting point of 20°C2.

Origin and Synthesis

BDO was first synthesized in 1890 by Dutch chemist Pieter Johannes Dekkers, who referred to it as tetramethylene glycol. Since then, its production has evolved significantly.

Industrial Synthesis Methods:

• Reppe Process: Involves the reaction of acetylene with formaldehyde to produce butyne-1,4-diol, which is then hydrogenated to yield BDO.
• Maleic Anhydride Route: Oxidation of benzene or butane produces maleic anhydride, which is converted to methyl maleate and then hydrogenated to form BDO.
• Biotechnological Route: Genetically modified microorganisms can produce BDO via biosynthesis from sugars, offering a more sustainable alternative2.

These methods are optimized for high yield and purity, with global production exceeding one million metric tons annually, primarily driven by demand in plastics and fibers.

Research and Industrial Applications

BDO is widely used in both academic and industrial research due to its chemical versatility.

Key Applications:

• Polymer Chemistry: BDO is a key monomer in the production of polybutylene terephthalate (PBT), a thermoplastic used in automotive and electronics.
• Solvent Production: It is dehydrated to form tetrahydrofuran (THF), a solvent critical in organic synthesis.
• Gamma-Butyrolactone (GBL): BDO is a precursor to GBL, which is used in the synthesis of pyrrolidones and other fine chemicals.
• Biomedical Research: Its conversion to gamma-hydroxybutyric acid (GHB) has led to studies on its effects on sleep, pain management, and neurological disorders.
• Cosmetics and Personal Care: Used as a humectant and solvent in moisturizers, hair care products, and nail treatments.

In research contexts, BDO’s reactivity allows scientists to explore new polymeric materials, drug delivery systems, and catalytic processes.

Storage and Handling

Proper storage of BDO is essential to maintain its stability and prevent degradation.

Storage Guidelines:

• Temperature: Store at approximately 20°C in a cool, dry place.
• Containers: Use sealed iron drums or bulk ISO tanks to prevent moisture absorption.
• Shelf Life: Up to 2 years if unopened and stored correctly.
• Precautions:
  • Use personal protective equipment (PPE) such as gloves and goggles.
  • Ensure adequate ventilation in storage and handling areas.
  • Prevent electrostatic discharge, which can pose fire risks.

Because BDO is hygroscopic, exposure to air can lead to contamination and reduced efficacy, especially in precision research applications.

Buy 1-4 BDO Online

 Legal Compliance and Safety

BDO’s legal status varies globally due to its potential misuse.

Regulatory Considerations:

• Controlled Substance Potential: BDO can be metabolized into GHB, a central nervous system depressant and Schedule I controlled substance in the U.S..
• Restricted Distribution: In some regions, including parts of the U.S. and Europe, BDO is regulated to prevent diversion for illicit use.
• Safety Data Sheets (SDS): Suppliers must provide comprehensive SDS documents outlining hazards, handling procedures, and emergency protocols.
• Product Stewardship: Companies must document intended industrial use and comply with local, state, and federal regulations before purchasing or distributing BDO.

Best Practices:

• Partner with reputable suppliers who offer technical support and regulatory guidance.
• Implement employee training programs on safe handling and disposal.
• Monitor inventory and usage to ensure compliance with legal thresholds.

In the EU, specific migration limits are set for BDO when used in food-contact materials, and compliance must be verified through migration testing rather than residual content analysis. GBL for Sale

Conclusion

1,4-Butanediol is a cornerstone chemical in modern industry and research. From its origins in 19th-century chemistry to its current role in advanced materials and biomedical studies, BDO exemplifies the intersection of utility and complexity. While its benefits are vast, responsible management—through proper storage, safety protocols, and legal compliance—is essential to harness its full potential safely.

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